Django always comes first to mind when we talk about a Python framework because it makes web development ridiculously fast and scalable. The software foundation is established as a non-profit organization and has a lot of senior developers and experts to help you out in case you are stuck. They keep updating the framework to match the latest version of Python. You can get the download and documentation from their own site as open-source software. It supports many database engines and is in use by major web applications like Instagram. As a newbie, you can start with this framework as it also makes learning much easier.